구성원
교수진
이재웅
- 직위 부교수
- 연구분야 B cell development/engineering, leukemia, lymphoma, and immunotherapy
- 전화번호 02-3290-5638
- 연구실 하나과학관 B동 564호
- 홈페이지 https://sites.google.com/view/leejlab
- 이메일 jaewoonglee@korea.ac.kr
학력
Ph.D. School of Life Science and Biotechnology, Kyungpook National University
M.S. School of Life Science and Biotechnology, Kyungpook National University
B.S. School of Life Science and Biotechnology, Kyungpook National University
M.S. School of Life Science and Biotechnology, Kyungpook National University
B.S. School of Life Science and Biotechnology, Kyungpook National University
경력 및 수상
2025 Yuhan Innovation Program Fellowship
2024 Samsung Science and Technology Foundation Fellowship
2023-present Associate professor, School of Biosystems and Biomedical Sciences, College of Health Science; Interdisciplinary Program in Precision Public Health, Korea University
2022-present Assistant professor (adjunct), Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University
2022-present Member of Yale Cancer Center
2022-2023 Assistant professor, School of Biosystems and Biomedical Sciences, College of Health Science; Interdisciplinary Program in Precision Public Health, Korea University
2020-2022 Research Scientist (faculty), Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University
2017-2020 Assistant Research Professor, Systems Biology, City of Hope Comprehensive Cancer Center
2013-2017 Postdoctoral Scholar, Laboratory Medicine, University of California, San Francisco
2012-2013 Postdoctoral Scholar, Children’s Hospital Los Angeles, University of Southern California
Awards
2019: American Society of Hematology, ASH Abstract Achievement Award
2018: American Society of Hematology, ASH Abstract Achievement Award
2017: American Society of Hematology, ASH Abstract Achievement Award
2016: American Society of Hematology, ASH Abstract Achievement Award
2015: American Society of Hematology, ASH Abstract Achievement Award
2013: American Society of Hematology, ASH Abstract Achievement Award
연구논문
1. Jaewoong Lee, Kohei Kume, Zhengshan Chen, Gang Xiao, Kadriye Nehir Cosgun, Liting Chen, Lai N. Chan, Lars Klemm, Chun-Wei Chen, Theodore L. Roth, Raju Pillai, Wing C. Chan, Stephen J. Forman, Larry W. Kwak, Francesca Zammarchi, Patrick H. Van Berkel, David M. Weinstock, Ari Melnick, Vu Ngo, Huimin Geng, Selina Luger, Mark Litzow, Alexandre Belot, Gulbu Uzel, Alexander Marson, Michael T. McManus, Elisabeth Paietta, Eric Meffre & Markus Müschen. CD25-dependent feedback control of the B-cell receptor and its oncogenic mimics. Nature. in revision (2022).
2. Mingli Li, Lu Yang, Anthony K.N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen-Han Chang, Kazuya Miyashita, Jun Wu, Jinhui Wang, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Him, Alexander J.R. Bishop, Chun-Wei Chen. Epigenetic control of protein translation and tumor progression via RUVBL1-EEF1A1 axis. Molecular Cancer. in review (2022).
3. Lili Pan*, Chao Hong*, Lai N Chan*, Gang Xiao, Parmanand Malvi, Mark E. Robinson, Huimin Geng, Srinivasa T. Reddy, Jaewoong Lee, Vishal Khairnar1 Kadriye Nehir Cosgun, Liang Xu, Kohei Kume, Teresa Sadras, Shaoyuan Wang, Narendra Wajapeyee & Markus Müschen. PON2 subverts metabolic gatekeeper functions in B-cells to promote leukemogenesis. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7). *These authors contributed equally to the study.
4. Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N. Chan, Kohei Kume, Teemu P. Miettinen, Ye Zhang, Matthew A. Nix, Lars Klemm, Chun Wei Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U. Jung, David M. Weinstock, Scott R. Manalis, Michael S. Diamond, Nagarajan Vaidehi & Markus Müschen. IFITM3 functions as PIP3-scaffold to amplify PI3K signaling in B-cells. Nature. 2020 Dec;588(7838):491-497
5. Lai N Chan, Mark A Murakami, Mark E Robinson, Rebecca Caeser, Teresa Sadras, Jaewoong Lee, Kadriye Nehir Cosgun, Kohei Kume, Vishal Khairnar, Gang Xiao, Mohamed A Ahmed, Eamon Aghania, Gauri Deb, Christian Hurtz, Seyedmehdi Shojaee, Chao Hong, Petri Pölönen, Matthew A Nix, Zhengshan Chen, Chun Wei Chen, Jianjun Chen, Andreas Vogt, Merja Heinäniemi, Olli Lohi, Arun P Wiita, Shai Izraeli, Huimin Geng, David M Weinstock, Markus Müschen. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 Jul;583(7818):845-851.
6. Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 Apr 5;173(2):470-484.e18.
7. Sullivan-Reed K, Bolton-Gillespie E, Dasgupta Y, Langer S, Siciliano M, Nieborowska-Skorska M, Hanamshet K, Belyaeva EA, Bernhardy AJ, Lee J, Moore M, Zhao H, Valent P, Matlawska-Wasowska K, Müschen M, Bhatia S, Bhatia R, Johnson N, Wasik MA, Mazin AV, Skorski T. Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep. 2018 Jun 12;23(11):3127-3136.
8. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 Feb 23;542(7642):479-483.
9. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signaling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61.
10. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 9;27(3):409-25.
11. Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood 2013 Aug 15;122(7):1293-304.
12. Jae-Woong Lee, Hyeng-Soo Kim, Seonggon Kim, Junmo Hwang, Young Hun Kim, Ga Young Lim, Wern-Joo Sohn, Suk-Ran Yoon, Jae-Young Kim, Tae Sung Park, Seung Hwan Oh, Kwon Moo Park, Zae Young Ryoo, Sanggyu Lee. Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9. Biochem Biophys Res Commun. 2012 Sep 28;426(3):299-305.
13. Jae-Woong Lee, Hyeng-Soo Kim, Seonggon Kim, Junmo Hwang, Young Hun Kim, Ga Young Lim, Wern-Joo Sohn, Suk-Ran Yoon, Jae-Young Kim, Tae Sung Park, Kwon Moo Park, Zae Young Ryoo, Sanggyu Lee. DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1. Biochem Biophys Res Commun. 2012 Mar 30;420(1):91-5.
14. Lee JW*, Kim E*, Baek DC, Lee SR, Kim MS, Kim SH, Kim CS, Ryoo ZY, Kang HS, Chang KT. *These Two authors contributed equally to this study. Processing and subcellular localization of ADAM2 in the Macaca fascicularis testis and sperm. Anim Reprod Sci. 2010 Jan;117(1-2):155-9.
15. Kim HS, Hwang J, Kim YH, Kim S, Lee JW, Kang HS, Kim KS, Ha JH, Chung JW, Chang KT, Ryoo ZY, Lee S. Detection of low-abundant novel transcripts in mouse hematopoietic stem cells. Mol Genet Genomics. 2009 Oct;282(4):363-70.
16. Kim E, Park KE, Kim JS, Baek DC, Lee JW, Lee SR, Kim MS, Kim SH, Kim CS, Koo DB, Kang HS, Ryoo ZY, Chang KT. Importance of the porcine ADAM3 disintegrin domain in sperm-egg interaction. J Reprod Dev. 2009 Apr;55(2):156-62.
17. Kim E, Lee JW, Baek DC, Lee SR, Kim MS, Kim SH, Imakawa K, Chang KT. Identification of novel retromer complexes in the mouse testis. Biochem Biophys Res Commun. 2008 Oct 10;375(1):16-21.
더보기
2. Mingli Li, Lu Yang, Anthony K.N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen-Han Chang, Kazuya Miyashita, Jun Wu, Jinhui Wang, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Him, Alexander J.R. Bishop, Chun-Wei Chen. Epigenetic control of protein translation and tumor progression via RUVBL1-EEF1A1 axis. Molecular Cancer. in review (2022).
3. Lili Pan*, Chao Hong*, Lai N Chan*, Gang Xiao, Parmanand Malvi, Mark E. Robinson, Huimin Geng, Srinivasa T. Reddy, Jaewoong Lee, Vishal Khairnar1 Kadriye Nehir Cosgun, Liang Xu, Kohei Kume, Teresa Sadras, Shaoyuan Wang, Narendra Wajapeyee & Markus Müschen. PON2 subverts metabolic gatekeeper functions in B-cells to promote leukemogenesis. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7). *These authors contributed equally to the study.
4. Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N. Chan, Kohei Kume, Teemu P. Miettinen, Ye Zhang, Matthew A. Nix, Lars Klemm, Chun Wei Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U. Jung, David M. Weinstock, Scott R. Manalis, Michael S. Diamond, Nagarajan Vaidehi & Markus Müschen. IFITM3 functions as PIP3-scaffold to amplify PI3K signaling in B-cells. Nature. 2020 Dec;588(7838):491-497
5. Lai N Chan, Mark A Murakami, Mark E Robinson, Rebecca Caeser, Teresa Sadras, Jaewoong Lee, Kadriye Nehir Cosgun, Kohei Kume, Vishal Khairnar, Gang Xiao, Mohamed A Ahmed, Eamon Aghania, Gauri Deb, Christian Hurtz, Seyedmehdi Shojaee, Chao Hong, Petri Pölönen, Matthew A Nix, Zhengshan Chen, Chun Wei Chen, Jianjun Chen, Andreas Vogt, Merja Heinäniemi, Olli Lohi, Arun P Wiita, Shai Izraeli, Huimin Geng, David M Weinstock, Markus Müschen. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 Jul;583(7818):845-851.
6. Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 Apr 5;173(2):470-484.e18.
7. Sullivan-Reed K, Bolton-Gillespie E, Dasgupta Y, Langer S, Siciliano M, Nieborowska-Skorska M, Hanamshet K, Belyaeva EA, Bernhardy AJ, Lee J, Moore M, Zhao H, Valent P, Matlawska-Wasowska K, Müschen M, Bhatia S, Bhatia R, Johnson N, Wasik MA, Mazin AV, Skorski T. Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep. 2018 Jun 12;23(11):3127-3136.
8. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 Feb 23;542(7642):479-483.
9. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signaling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61.
10. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 9;27(3):409-25.
11. Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood 2013 Aug 15;122(7):1293-304.
12. Jae-Woong Lee, Hyeng-Soo Kim, Seonggon Kim, Junmo Hwang, Young Hun Kim, Ga Young Lim, Wern-Joo Sohn, Suk-Ran Yoon, Jae-Young Kim, Tae Sung Park, Seung Hwan Oh, Kwon Moo Park, Zae Young Ryoo, Sanggyu Lee. Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9. Biochem Biophys Res Commun. 2012 Sep 28;426(3):299-305.
13. Jae-Woong Lee, Hyeng-Soo Kim, Seonggon Kim, Junmo Hwang, Young Hun Kim, Ga Young Lim, Wern-Joo Sohn, Suk-Ran Yoon, Jae-Young Kim, Tae Sung Park, Kwon Moo Park, Zae Young Ryoo, Sanggyu Lee. DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1. Biochem Biophys Res Commun. 2012 Mar 30;420(1):91-5.
14. Lee JW*, Kim E*, Baek DC, Lee SR, Kim MS, Kim SH, Kim CS, Ryoo ZY, Kang HS, Chang KT. *These Two authors contributed equally to this study. Processing and subcellular localization of ADAM2 in the Macaca fascicularis testis and sperm. Anim Reprod Sci. 2010 Jan;117(1-2):155-9.
15. Kim HS, Hwang J, Kim YH, Kim S, Lee JW, Kang HS, Kim KS, Ha JH, Chung JW, Chang KT, Ryoo ZY, Lee S. Detection of low-abundant novel transcripts in mouse hematopoietic stem cells. Mol Genet Genomics. 2009 Oct;282(4):363-70.
16. Kim E, Park KE, Kim JS, Baek DC, Lee JW, Lee SR, Kim MS, Kim SH, Kim CS, Koo DB, Kang HS, Ryoo ZY, Chang KT. Importance of the porcine ADAM3 disintegrin domain in sperm-egg interaction. J Reprod Dev. 2009 Apr;55(2):156-62.
17. Kim E, Lee JW, Baek DC, Lee SR, Kim MS, Kim SH, Imakawa K, Chang KT. Identification of novel retromer complexes in the mouse testis. Biochem Biophys Res Commun. 2008 Oct 10;375(1):16-21.
학부,대학원 담당과목
학부: 면역학, 내분비학
대학원: 응용분자면역학, 고급종양면역학, 암세포생물학, 면역질환병리학
더보기
대학원: 응용분자면역학, 고급종양면역학, 암세포생물학, 면역질환병리학
